Protein Thermal Stability Enhancement by Designing Salt Bridges: A Combined Computational and Experimental Study
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چکیده
منابع مشابه
Protein Thermal Stability Enhancement by Designing Salt Bridges: A Combined Computational and Experimental Study
Protein thermal stability is an important factor considered in medical and industrial applications. Many structural characteristics related to protein thermal stability have been elucidated, and increasing salt bridges is considered as one of the most efficient strategies to increase protein thermal stability. However, the accurate simulation of salt bridges remains difficult. In this study, a ...
متن کاملDefining the role of salt bridges in protein stability.
Although the energetic balance of forces stabilizing proteins has been established qualitatively over the last decades, quantification of the energetic contribution of particular interactions still poses serious problems. The reasons are the strong cooperativity and the interdependence ofnoncovalent interactions. Salt bridges are a typical example. One expects that ionizable side chains frequen...
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Insulin hormone is an important part of the endocrine system. It contains two polypeptide chains and plays a pivotal role in regulating carbohydrate metabolism. Insulin receptors (IR) located on cell surface interacts with insulin to control the intake of glucose. Although several studies have tried to clarify the interaction between insulin and its receptor, the mechanism of this interaction r...
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Insulin hormone is an important part of the endocrine system. It contains two polypeptide chains and plays a pivotal role in regulating carbohydrate metabolism. Insulin receptors (IR) located on cell surface interacts with insulin to control the intake of glucose. Although several studies have tried to clarify the interaction between insulin and its receptor, the mechanism of this interaction r...
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absorbed in the atmosphere, the NIR water vapor bands. Thus, we see no way of defending Stephen's statement that conclusions based on broad-band measurements (1) are inconsistent with other existing data sets where discrepancies were found to occur between measurements in spectral bands and theory. Instead, the broad-band solar absorption findings presented in our report (1) are entirely consis...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0112751